This product is used as a reagent for trimethylsilyl derivatization before gas chromatography. N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) alone cannot completely derivatize amides, secondary amines and sterically-hindered hydroxyl groups. However, derivatization of such moieties becomes possible just by adding TMCS at a ratio of 1 to 20 %.
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