Microcarriers

Introduction of Microcarriers

Microcarriers are 100~300 μm diameter support matrices on which adherent cells attach and grow. Microcarriers possess a greater surface area-to-volume ratio than single-cell monolayers. By means of culturing cells on the surface of spherical microcarriers, each particle can carry numerous cells, ultimately facilitating large-scale and efficient cell production. The large surface area of microcarriers can effectively enhance the expansion of anchorage-dependent cells and proteins, which can further promote the repair and regeneration of tissues. The expansion capacity, homogeneity, physiological microenvironment, and biocompatibility of microcarriers over traditional cell culture have further promoted their widespread use in life science research.

Advantages of Our Microcarriers in Biotechnology Industry

• Precisely control growth conditions for cells in intricate bioreactors
• Reduce incubator volume, floor space, and labor
• Create a more suitable culture environment that can promote cell differentiation

Fig. 1 Representation of microcarrier cell culture technologies. Porous microcarriers are presented here as an example. (Chen X Y, et al., 2020)

Microcarrier composition includes synthetic, natural, solid, and porous microcarriers. In recent years, natural polymers and their derivatives have received increasing attention due to their easy availability and biocompatibility. Natural polymers used to make microcarriers include gelatin (GELI BEAD, Ventregel, and CultiSpher), alginic acid, chitosan, cellulose (Cytopore), collagen (Verax), etc.

Types of Our Microcarriers

• MCdex-01
• MCdex-01G
• MCdex-03
• MCpore-01
• MCpore-02
• MCdex-03G

Application Fields of Our Microcarriers

• Production of high-volume cell, viral, and recombinant cell products
• Research on cell adhesion, differentiation, and cell function
• Study of cell behavior in vitro
• Clinical applications in wound healing and tissue engineering systems (tissue repair and regeneration)
• Cell isolation, storage, and transport
• Assays involving cell transfer and uptake of labeled compounds

Creative BioMart provides a wide range of microcarriers for the industrial production of cell or protein therapy as well as scientific research. Our products cover various types of microcarriers to meet your experimental cell culture needs. You can quickly find the reagents you need by searching keywords such as CAT number or product name. Please tell us your product needs, we will provide you with a comprehensive consultation. If you have any questions, please feel free to contact us.

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Reference:

1. Chen X Y, Chen J Y, Tong X M, et al. (2020) Recent advances in the use of microcarriers for cell cultures and their ex vivo and in vivo applications[J]. Biotechnology Letters. 42(1): 1-10.