Depending on resolution requirements and application, the SP Strong Cation Exchange Resin series is available in three grades: Fast Flow SP Strong Cation Exchange Resin (~90 μm), High-Performance SP Strong Cation Exchange Resin (~35 μm), and Large-Bead SP Strong Cation Exchange Resin (~200 μm). Fast Flow SP Strong Cation Exchange Resin offers fast flow rates for rapid protein purification with broad applicability and easy scale-up. High-Performance SP Strong Cation Exchange Resin delivers high resolution and is mainly used in polishing steps. Large-Bead SP Strong Cation Exchange Resin features large particle size for high-viscosity systems such as blood products and can also be used in batch-mode static operations. SP is a strong acid group with a recommended working pH range of 3–13, broader than that of weak cation-exchange resins.
Matrix
6% Cross-linked agarose
Average particle size
~90 μm
Dry Particle Size Range
45–165 μm
Ligand
Sulfopropyl (SP)
Capacity
160–220 μmol H+/mL
Dynamic binding capacity
≥ 120 mg / mL
Chemical stability
Stable in common aqueous solutions: 1 M NaOH, 8 M urea, 6 M guanidine HCl, 70% ethanol, etc.