| Product Information | |
| Cat#No# | 350PL-009C |
| Product Overview | The FineLINE portfolio consists of medium pressure chromatography columns with a pressure rating of up to 2 MPa (20 bar, 290 psi). The columns are specially designed for use with SOURCE ion exchange (IEX), hydrophobic interaction (HIC), and reversed phase (RPC) chromatography resins. These rigid high-resolution resins are often used in manufacturing of, for example, insulin. FineLINE columns are equipped with a hydraulically adjustable adaptor enabling fast and reproducible packing. The column design allows a high standard of hygienic operation suitable for biomanufacturing. They are compatible with liquids commonly used in large-scale chromatography. |
| Characteristic | Fast packing. Reproducible scale-up. Stable beds with SOURCE 15 and SOURCE 30 resins. |
| Maximum operating pressure | 20 bar (280 psi) |
| Recommended column height | 50-300 mm |
| Temperature stability | 4°C-40°C |
| Autoclavable | 121°C for 30 min |
| Sanitization | A sanitization study using microbial challenge testing was performed on a FineLINE 100 column. Sanitization efficiency was tested after the column. The column was packed with chromatography resin and infected with three strains of bacteria. Following infection, the column was sanitized with sodium hydroxide. After the sanitization cycle had been completed, microbial samples were taken from the eluate at the column outlet, selected surfaces inside the column, as well as from the resin packed in the column. |
| Column i.d. | 350 mm |
| Adapter Movement | Internal Hydraulic |
| Bed support | Screen |
| Bed Volume Max. | 28.8 l |
| Bed Volume Min. | 4.8 l |
| Column Cross Section Area | 962 cm² |
| Connections | 25 mm TC |
| Footprint | 590 x 590 mm |
| Material (bed support) | 316L Stainless Steel (SS) |
| Material (column tube) | Electropolished Stainless Steel (SS)316 L |
| Material (Distributor) | 316 L Stainless Steel |
| Material (Lid) | 316L Stainless Steel (SS) |
| Material (Seal) | Ethylene Propylene Diene (EPDM) |
| Material (Stand) | Stainless Steel (SS) |
| Weight | 260 kg |
| Porosity | 2 µm |
| Surface Finish, Stainless Steel Internal Wetted | Ra Electropolished'< 0.5 µm |
| Surface Finish Stainless Steel Non-Wetted Parts | Ra Electropolished < 3 µm |
| Tube height | 700 mm |
| Outer Height | 2150 mm |
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