The Magrose Heparin series of magnetic beads feature rapid magnetic responsiveness, abundant heparin density, and high physicochemical stability. The heparin coupled to the surface of this magnetic bead product carries a large number of negatively charged sulfate ion groups. Under a certain pH value, it can have a strong binding ability with positively charged proteins. Meanwhile, heparin can bind to growth factors and antithrombin AT Ⅲ through specific affinity. Therefore, the target factor can be rapidly and efficiently purified from plasma in one step through magnetic separation. Compared with the traditional column chromatography purification method, the Magrose Heparin series magnetic beads do not require pretreatment of crude protein samples (such as repeated and cumbersome centrifugation, time-consuming and laborious filtration operations). In addition, there is no need to control the flow rate and column pressure, and expensive chromatography equipment is not required. For skilled operators, the extraction of high-purity target proteins can be completed in a very short time, and parallel processing of multiple samples can be easily achieved, realizing high-throughput protein purification. This magnetic bead product can be applied to the separation and purification of biomolecules such as anticoagulant factor III, coagulation factor, interferon, nucleic acid binding protein, lipoprotein, protein synthesis factor, restriction endonuclease, thrombin and thrombin.
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