HiScale columns

• Cat#No#: Hi-011C
• Product Overview: HiScale empty chromatography columns are a family of pressure-stable, easy to pack, columns for medium to high pressure liquid chromatography using a chromatography system.
• Description: HiScale is a family of pressure-stable empty columns designed for preparative chromatography, process development, and process validation such as scale-down studies. The user-friendly design allows for an optimized process through simplified and reproducible operation. The range of functional advantages makes HiScale columns well-suited for work that requires ease-of-use, robustness, and process control.
• Characteristic: Easy to pack: convenient column measurement scale, nonrotating plunger mechanism, and ergonomically designed components for easier adjustment during column packing.
  Pressure-stable: built to withstand pressures up to 20 bar (2 MPa, 290 psi) for compatibility with modern BioProcess resins.
  Versatile: dual adapters and axial compression capability allow for a large range of bed heights and column packing protocols.
  Variety of column dimensions: choose from 10, 16, 26, or 50 mm inner diameter, and 200 mm or 400 mm length to accommodate bed volumes up to 785 mL.
  Scalable: the HiScale column range is designed to facilitate robust process scaleup, as well as cost-efficient and accurate scaledown for applications such as viral clearance studies.
  High flexibility: equipped with two adapters allowing for a large range of bed heights.
• Maximum operating pressure: 20 bar (2 MPa, 290 psi)
• Chemical stability: The columns are designed to be used in aqueous solutions and most organic solvents commonly used in liquid chromatography of biomolecules, with the following few exceptions: chlorinated hydrocarbons, acetone and other ketones, aliphatic esters, and phenol. Solutions containing more than 2 M NaOH, 1 M HCl, other strong mineral acids, or 75% acetic acid should not be used. The column may be used at temperatures from 4°C to 40°C and at pressures up to 20 bar (2 MPa, 290 psi).
• Column i.d.: 16 mm
• Bed support: Net
• Material (bed support): Polypropylene (PP) (reinforced glass fiber), Polyamide (PA).
• Material (column tube): Borosilicate glass, Polycarbonate, Polyamide (reinforced glass fiber), Ethylene propylene diene polymer (EPDM), Polyoxymetylen (POM), Fluoro-rubber (Viton), Polypropylene, Polyamide (nylon).
• Porosity: 20 μm
• Material (column hardware): Borosilicate glass, Polycarbonate, Polyamide (reinforced glass fiber), Ethylene propylene diene polymer (EPDM), Polyoxymetylen (POM), Polyether ether ketone (PEEK), Ethylenetetrafluoroethylene (ETFE), Fluoro-rubber (Viton), Polypropylene, Polyamide (nylon).
• Tube height: 400 mm