| Cat# | Product Name | Size | Price | Qty | Inquiry |
|---|---|---|---|---|---|
| Hi-142P | HiScreen Capto PlasmidSelect | Inquiry |
| Product Information | |
| Cat#No# | Hi-142P |
| Product Overview | Capto PlasmidSelect is a chromatography resin that allows supercoiled covalently closed circular forms of plasmid DNA to be separated from open circular forms. |
| Description | Capto PlasmidSelect is a thiophilic aromatic adsorption chromatography resin with a selectivity that allows supercoiled covalently closed circular forms of plasmid DNA to be separated from open circular forms. The resin is designed for purification of supercoiled DNA to high quality for gene therapy and DNA vaccine applications. Compared with its predecessor PlasmidSelect Xtra resin, Capto PlasmidSelect is based on a more rigid base matrix, delivering excellent pressure-flow properties to plasmid production. The possibility to run at higher flow rates and bed heights increases flexibility in process design and allows for an increased productivity. Capto PlasmidSelect is available in bulk as well as in formats suitable for process development. |
| Characteristic | High-flow purification of supercoiled DNA from research scale to cGMP production. Flexible process design due to a large operational window of flow velocities and bed heights. Higher throughput for improved productivity and process economy. Hydrophilic properties of base matrix prevent non-specific binding. BioProcess resin supported for industrial applications. Convenient small-scale purification, process development, and scale-up using prepacked HiScreen columns. |
| Maximum operating pressure | 8 bar (0.8 MPa) |
| Matrix | Highly cross-linked agarose, spherical |
| Particle Size | 36–44 µm |
| Ligand | 2-mercaptopyridine |
| Ligand density | 27–50 µmol/mL |
| Dynamic binding capacity | ≥ 3.0 mg/mL |
| Recommended flow rate | 220 cm/h |
| Chemical stability | Stable in up to 1 M NaOH, 40% Isopropanol, up to 1 M acetic acid, and up to 70% ethanol. |
| pH working range | 3 to 13 |
| CIP stability | 2 to 14 |
| Storage | 20% ethanol at temperatures between 4°C and 30°C. |
| Shipping | 20% ethanol |
| Pack size | 4.7 mL |
| Dimensions | 0.77 × 10 cm |
| Column volume | 4.7 mL |
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For Research or Industrial Raw Materials, Not For Personal Medical Use!Online Inquiry
