This gene encodes the minor subunit of the asialoglycoprotein receptor, a transmembrane protein critical for serum glycoprotein homeostasis. This receptor mediates the endocytosis and lysosomal degradation of glycoproteins with terminal galactose or N-acetylgalactosamine residues. It may also facilitate hepatic infection by viruses like hepatitis B and serves as a target for liver-specific drug delivery.