Mixed-Mode Ion Exchange Resins combine ionic, hydrophobic, hydrogen-bonding, and other secondary interactions within a single chromatography medium, providing unique selectivity beyond conventional ion-exchange resins. These resins maintain favorable binding performance over a broad range of buffer conditions, including elevated salt concentrations, making them suitable for purification of antibodies, recombinant proteins, plasma proteins, enzymes, viral particles, and other biomolecules. Available in multiple particle sizes, they support both process development and large-scale bioprocessing applications.
Matrix
Highly rigid agarose
Average particle size
~60 μm
Capacity
80–120 µmol OH-/mL
Chemical stability
Stable in common aqueous solutions: 1 M NaOH, 8 M urea, 6 M guanidine HCl, 70% ethanol, 30% isopropanol, etc.