Plasmid Capture Resin

• Product Overview: This thiophilic affinity resin is prepared by immobilizing 2-mercaptopyridine onto fine, high-rigidity agarose beads. Optimized ligand density provides suitable affinity for supercoiled DNA, and the fine beads enhance binding capacity for large plasmids. It is suitable for large-scale plasmid purification in gene therapy, DNA vaccines, mRNA vaccines, and lentivirus processes.
• Matrix: High-rigidity agarose
• Appearance: White paste, may separate upon standing
• Wet Particle Size Range: 36–44 μm
• Ligand: 2-Mercaptopyridine
• Dynamic binding capacity: > 2 mg Supercoiled plasmid / mL packed resin
• Coupling chemistry: Epoxy chemistry with 2-mercaptopyridine
• pH working range: 3–11
• pH CIP range: 2–13
• Chemical stability: Stable in common aqueous solutions: 1 M acetic acid, 30% isopropanol, 70% ethanol, 0.1 M NaOH
• Maximum operating pressure: 0.5 MPa
• Maximum flow velocity: ≥ 300 cm/h
• Pack size: 25 mL; 100 mL; 500 mL; 1 L; 5 L; 10 L
• Storage: 2–30 °C in 20% ethanol or 2% benzyl alcohol
• Product features: 2-Mercaptopyridine ligand affinity resin.
  Separates supercoiled from open circular plasmid DNA.
  Stable and efficient, suitable for industrial plasmid production.