Strong Anion Exchange Resin (High Capacity)

• Product Overview: Ion exchange chromatography (IEC) is a highly effective method for separating and purifying biomolecules, relying mainly on interactions between positive and negative charges. It separates biomolecules based on differences in charge type and quantity under specific conditions, offering high binding capacity, high resolution, controllable conditions, and easy scalability. Widely used in pharmaceuticals, chemical engineering, metallurgy, and food industries. The ion exchange medium consists of three components: (1) a cross-linked network matrix with porous, hydrophilic, and chemically stable properties. Modification of traditional agarose gives it higher mechanical strength, known as high-rigidity agarose ( matrix); (2) functional groups attached to the matrix, which are charged groups determining the medium’s properties; (3) counter-ions with opposite charge to the functional groups, which can reversibly bind to them. high-capacity strong anion exchanger couples long-chain dextran onto high-rigidity agarose microspheres, then cross-links quaternary ammonium groups on the dextran, reducing steric hindrance between biomolecules and ligands, significantly improving the dynamic binding capacity for target molecules.
• Matrix: High-rigidity agarose with dextran chains
• Appearance: White paste, may separate upon standing
• Wet Particle Size Range: 36–44 μm
• Ligand: Quaternary ammonium
• Dynamic binding capacity: > 100 mg BSA / mL packed resin
• Coupling chemistry: Quaternary ammonium functionalization
• Chemical stability: Stable in common aqueous solutions: 1 M NaOH, 6 M guanidine HCl, 30% isopropanol, 70% ethanol
• Maximum operating pressure: 0.5 MPa
• Pack size: 25 mL; 100 mL; 500 mL; 1 L; 5 L; 10 L; 20 L; 40 L
• Storage: 2–30 °C in 20% ethanol or 2% benzyl alcohol
• Product features: High-resolution, high-capacity strong anion exchange resin; uses high-rigidity, high-resolution agarose matrix; suitable for medium or fine purification of large-scale samples in industrial production; stable physical and chemical properties with long service life; widely applied for separation/purification of proteins, nucleic acids, and peptides in biopharmaceuticals and bioengineering.