Creative BioMart Chromatography has professional teams to provide chiral separation services from milligram to hundreds of kilograms, with high efficiency, high quality, and reasonable price. We have a wealth of experience and advanced instruments, including analytical SFC-MS, prep-SFC, and mass triggered prep-HPLC.
Chirality is a common phenomenon in nature, and the basic substances that constitute living organisms, such as most amino acids and sugars, are chiral molecules. Drug enantiomers in the body in most cases will show different therapeutic effects and even adverse reactions. Research on chiral drugs is the development trend of pharmaceutical chemistry. Using a single isomer to replace the mixed drug used in clinical applications is also one of the ways to develop new drugs. With the deepening understanding of chiral molecules, the demand for single chiral substances is increasing, and the requirements for its purity are getting higher and higher. The preparation of chiral drugs or intermediates by chiral separation of racemes obtained by ordinary chemical synthesis is the main method for the industrial production of chiral drugs.
Supercritical fluid chromatography (SFC) has been widely used in small molecule drug development strategies by various drug research and development institutions. It is certain that SFC will be applied in the development process of chiral candidate drugs for a long time, including the screening of chiral analysis methods for determining API and chiral purity of intermediates. As well as the development of chiral separation methods scaling up. The prep-SFC can be used for chiral separation from milligram to kilogram. In many cases, the yield of SFC purified samples from the same library is higher than that of HPLC. (Fig. 1) The low viscosity and high diffusivity of the mobile phase in the SFC allow for higher flow rates and lower pressure drops compared to traditional HPLC. In addition, SFC requires less organic or aqueous organic solvents than LC and provides another normal phase retention mechanism. (Pinkston J. D., et al, 2006)
Fig. 1 Purified product yields for one high-throughput organic synthesis library. (Searle, P. A., et al, 2004)
What We Offer
- Chiral separation method development.
- Milligram scale and Large scale (up to hundreds of kg) chiral separations.
- High-throughput purification for synthetic compounds.
- Large scale chiral purification.
- GMP service is capable.
Our Specialty
- Advanced platform, professional technology.
- Competitive prices within the industry.
- Faster response, higher efficiency.
- Keep in touch and respond to all your questions.
Creative BioMart Chromatography has been providing chiral separation services to customers around the world for decades. We have a wealth of experience, advanced infrastructure, as well as provide reasonable quotations to meet customers' requirements in chiral separation. We have achieved many kg level separations through the SFC, including GMP conditions. Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our services, please contact us.
How to Place an Order
*If your organization requires the signing of a confidentiality agreement, please contact us by email.
References:
- Pinkston J. D., et al. (2006). Comparison of LC/MS and SFC/MS for screening of a large and diverse library of pharmaceutically relevant compounds. Anal Chem. 78 (21), 7467-7472.
- Searle, P. A., et al. (2004). Comparison of preparative HPLC/MS and preparative SFC techniques for the high-throughput purification of compound libraries. J. Comb. Chem. 6 (2), 175–180.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.