Creative BioMart Chromatography provides glycan analysis services to aid your biopharmaceutical research. Glycans consist mainly of monosaccharides, oligosaccharides, and polysaccharides, which are conjugated with proteins or lipids to form glycoconjugates. The diversity of glycan structure determines that glycoconjugates contain abundant information about cell and disease states. Glycosylation is a post-translational modification (PTM), a non-template-driven enzymatic modification process. It is affected by cell lines and other environmental factors. Changes in N-glycosylation and O-glycosylation may affect the clinical safety and efficacy of biopharmaceuticals. Our glycan analysis experts provided detailed glycosylation studies based on relevant EMA, FDA and ICH guidelines. Our analytical services are designed to support customers throughout the entire biopharmaceutical development, product characterization and regulatory submission process. We use the latest methods and technologies, our solutions include but are not limited to ion chromatography (IC), HPLC, UHPLC, LC-MS, TLC, HILIC, IEX, CE-LIF, GC-MS, etc.
Fig. 1 Schematic representation of N-linked and O-linked glycans on glycoproteins and glycolipids. (Zhang Z. J., et al, 2018)
Glycan Analysis Categories
- Monosaccharide analysis
- Sialic acid analysis
- N-glycans and O-glycans analysis
- Glycopeptide analysis
Test Items
1. Monosaccharide indicators: mannose, glucose, galactose, fucose, N-acetylglucosamine, N-acetylgalactosamine, etc.
2. Sialic acid indicators: Neu5Ac, Neu5Gc, etc.
3. Analysis of glycosylation sites
4. Glycan structure
Our Specialty
- The technical team is experienced in testing and arranges the experiments in a timely and rigorous manner.
- Standard calibration of testing equipment on time to ensure accurate and reliable test data.
- Professionals analyze test data and assist in solving technical problems effectively.
- Perfect and thoughtful pre-sales and after-sales service, and timely solve customers' questions.
Creative BioMart Chromatography designs and performs appropriate glycan analysis procedures and can work up to GMP standards. We offer comprehensive and professional analysis results to help you meet and exceed quality, safety and regulatory standards. We can also transfer and validate these optimized glycan analysis methods to your laboratory. Our customers have direct access to our experts and give timely feedback to any online inquiries. If you are interested in our services, please contact us.
How to Place an Order
*If your organization requires the signing of a confidentiality agreement, please contact us by email.
Reference:
- Zhang Z. J., et al. (2018). Serum sialylation changes in cancer. Glycoconjugate Journal. 35, 139-160.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.